Table 2

Relationship between HCC and demographic and biochemical variables

P valueUnivariate analysisP valueMultivariate analysis
OR (95% CI)OR (95% CI)
Age (years)0.389
Gender (male vs female)0.687
Total bilirubin (mg/dL)0.001*1.688 (1.243 to 2.293)0.242
ALT (U/L)<0.001*1.036 (1.022 to 1.051)0.923
AST (U/L)<0.001*1.030 (1.018 to 1.041)0.270
ALK (U/L)0.044*1.012 (1.000 to 1.023)0.121
Albumin (g/dL)<0.001*0.434 (0.278 to 0.679)0.152
INR0.029*1.067 (1.055 to 2.641)0.137
AFP (ng/mL)<0.001*1.012 (1.007 to 1.016)0.001*1.016 (1.006 to 1.026)
NRP-1 (pg/mL)<0.001*1.002 (1.001 to 1.003)0.002*1.002 (1.001 to 1.003)
ANG-2 (pg/mL)<0.001*1.001 (1.001 to 1.002)0.122
  • *P<0.05 significant.

  • AFP, alpha-fetoprotein; ALK, alkaline phosphatase; ALT, alanine transaminase; ANG-2, angiopoietin-2; AST, aspartate transaminase; HCC, hepatocellular carcinoma; INR, international normalized ratio; NRP-1, neuropilin-1.