Table 1

Demographic, clinical and laboratory characteristics of the studied groups

CharacteristicsGroup I (HCC)
Group II (cirrhosis)
Group III (healthy control)
P value
Age (years)59.2±6.758.8±6.357.5±7.10.422
Gender, n (%)0.720
Male27 (54.0)23 (46.9)27 (54.0)
Female23 (46.0)26 (53.1)23 (46.0)
Ascites, n (%)26 (52.0)33 (67.3) 0.120
Lower limb edema, n (%)34 (68.0)39 (79.6) 0.190
Total bilirubin (mg/dL)2.2±1.2†2.4±0.9†0.6±0.2<0.001*
ALT (U/L)76±32†68±19†20±6<0.001*
AST (U/L)95±43†79±25†24±7<0.001*
ALK (U/L)96±29†106±27†64±19<0.001*
Albumin (g/dL)2.7±0.8†2.5±0.4†4.0±0.4<0.001*
AFP (ng/mL)356.1±257.3†‡155.2±65.6†4.9±2.0<0.001*
NRP-1 (pg/mL)2221.8±1056.6†‡1108.9±526.6†219.3±61.8<0.001*
ANG-2 (pg/mL)3018.5±841.4†‡2179.1±599.22007.7±904.8<0.001*
  • Data are expressed as mean±SD.

  • *P<0.05 significant.

  • †Significant with group III.

  • ‡Significant with group II.

  • AFP, alpha-fetoprotein; ALK, alkaline phosphatase; ALT, alanine transaminase; ANG-2, angiopoietin-2; AST, aspartate transaminase; HCC, hepatocellular carcinoma; INR, international normalized ratio; NRP-1, neuropilin-1.