Table 3

Daily insulin doses requirements by metabolic control subgroups in T1D using glargine U300 or degludec

HbA1c ≤7%
(IGla: 65 P; IDeg: 48 P)
HbA1c 7.1%–8%
(IGla: 69 P; IDeg: 82 P)
HbA1c ≥8%
(IGla: 53 P; IDeg: 95 P)
P valueP valueP value
Basal insulin
Unit/day
 IGla-30025.8±13.40.78130.8±15.70.78035.1±13.80.779
 IDeg26.6±16.831.6±19.035.8±18.1
Unit/kg/day
 IGla-3000.36±0.160.5580.43±0.170.8700.51±0.180.643
 IDeg0.38±0.200.42±0.210.49±0.21
Prandial insulin
Unit/day
 IGla-30018.7±12.40.55225.1±19.90.05524.5±14.60.185
 IDeg20.0±9.819.7±11.128.4±20.2
Unit/kg/day
 IGla-3000.26±0.170.4040.35±0.270.0700.37±0.210.451
 IDeg0.29±0.110.27±0.160.40±0.26
Total insulin
Unit/day
 IGla-30044.7±22.20.89356.2±32.30.28559.6±24.70.342
 IDeg45.3±24.151.0±25.164.3±33.2
Unit/kg/day
 IGla-3000.64±0.290.8570.79±0.370.1350.88±0.340.782
 IDeg0.64±0.240.69±0.280.89±0.38
B/T ratio
 IGla-3000.60±0.150.0320.58±0.150.2170.60±0.130.269
 IDeg0.55±0.110.61±0.140.57±0.15
  • B/T, basal/total insulin; HbA1c, glycosylated hemoglobin; IDeg, insulina degludec; IGla-300, insulina glargina 300 UI/mL; P, patients; T1D, type 1 diabetes.