Main evaluation of clinical outcomes before and after PFO closure
| Clinical outcomes | 0M | 3M | 6M | 12M |
| Frequency (per month) | 11.53±11.06 | 3.92±7.47 | 3.23±6.97 | 2.84±6.81 |
| Duration (hours) | 12.43±15.25 | 4.64±11.04 | 4.34±10.88 | 4.00±10.40 |
| VAS score | 4.57±2.17 | 1.66±1.60 | 1.55±1.51 | 1.44±1.45 |
| HIT-6 score | 61.18±7.97 | 43.65±9.17 | 43.06±8.95 | 42.70±8.76 |
HIT-6, Headache Impact Test; 0M, preoperatively; 3M, at 3 months postoperatively; 6M, at 6 months postoperatively; 12M, at 12 months postoperatively; PFO, patent foramen ovale; VAS, Visual Analogue Scale.