Table 2

Comparison of the prevalence of the BRAF p.V600E variant among Latin American and Caribbean populations and description of the clinicopathological data of positive individuals

Country/authorsNumber of patientsMale/female %Mean or median age (range)Tumor location %Tumor stage (%) BRAF p.V600E frequency*P value
Western Mexico/
This study
10155/4560 (19–96)Right colon 26
Left colon 62
Ubiquitous 12
I–II=37
III–IV=61
ND=2
4/101 (4%)
Northeast Mexico/
Luévano-González et al 33
10655/45<50=58
≥50=48
Right colon 45
Left colon 55
T2=23†
T3=19
T4=58
0/97 (0%)0.12
Central Mexico/
González-Colunga et al 34
135‡58/4255 (45–65)§Right colon 59
Left colon 41
I–II=28
III–IV=72
13/135 (9.6%)0.13
Peru/
Montenegro et al 35
90NDNDNDND9/90 (10%)0.14
Peru/
Egoavil et al 36
90 patients (91 samples)49/5159.3 (22–89)Right colon 36
Left colon 63
ND 1
I–II=51
III–IV=49
9/91 (9.9%)0.14
Brazil/
Rasuck et al 37
7740/6063 (ND)Right colon 35
Left colon 61
ND 4
All stages5/77 (6.5%)0.50
Brazil/
Yamane et al 10
15553/4766 (50–89)Right colon 47
Left colon 53
ND9/103 (8.7%)¶0.25
Brazil/
Pereira-Zambalde38
8445/5565 (36–89)Colon 54
Rectum 34
ND 12
0–II=36
III–IV=31
ND=33
0/84 (0%)0.12
Brazil/
dos Santos et al 39
9154/4661.1 (29–88)Right colon 22
Left colon 78
0–II=78
III–V=22
6/91 (6.6%)0.52
Chile/
Roa et al 28
10044/5661 (ND)Colon 88
Rectum 6
Hepatic metastasis 5
ND 1
“Advanced” stages11/94 (12%)0.06
Chile/
Hurtado et al 29
58‡48/5263.5 (35–90)Right colon 33
Left colon 67
I–II=59
III–IV=41
5/58 (9%)0.28
Chile/
Alvarez et al 30
5659/4164 (45–97)Right colon 37
Left colon 63
0–II=61
III–IV=36
ND=3
At least 4/56 (7.1%)0.45
Chile/
Wielandt et al 15
5355/4570 (41–97)Right colon 38
Left colon 62
I–II=45
III–IV=55
8/53 (15%) 0.02
Argentina/
Perazzo et al 40
14658/4258.1 (17–88)Right colon 28
Left colon 69
I–II=27
III–IV=73
6/49 (12.2%)0.08
Argentina/
Lopez-Ruitti et al 41
8554/4664 (28–85)NDND4/45 (8.9%)0.25
Argentina/
González et al 42
15556/4465.6 (ND)Right colon 35
Left colon 65
I–II=54
III–IV=46
11/112 (9.8%)0.11
Puerto Rico/
Perez-Mayoral et al 43
120NDNDNDND11/120 (9.17%)0.17
Paraguay/
Fleitas-Kanonnikoff et al 44
3664/3652 (20–74)Right colon 39
Left colon 61
I–III=17
IV=83
2/36 (5.5%)0.65
Total1738117/1492 (7.8)
  • *BRAF p.V600E frequency established based only on the number of patients analyzed for the variant.

  • †Primary tumor invasion.

  • ‡Patient with colon cancer.

  • §Median (IQR) only for wild-type BRAF patients.

  • ¶Described as precursor lesions, not as patients.

  • ND, no data.