Definitions of acute and long-term response
Acute pulmonary vasoreactivity for patients with idiopathic, heritable or drug-induced PAH. | Reduction of mPAP >10 mm Hg to reach an absolute value of mPAP <40 mm Hg. |
Increased or unchanged cardiac output. | |
Long-term response to CCBs. | New York Heart Association functional class I/II. |
With sustained hemodynamic improvement (same or better than achieved in the acute test) after at least 1 year on CCBs only. |
CCBs, calcium channel blockers; mPAP, mean pulmonary arterial pressure; PAH, pulmonary arterial hypertension.