Table 2

Univariate and multivariate cox regression analyses for overall survival in patients with nasopharyngeal carcinoma in the primary cohort

VariablesUnivariate analysisMultivariate analysis
 HR (95% CI)P valuesHR (95% CI)P values
Sex
 Female versus male0.55 (0.31 to 0.97)0.038*0.68 (0.38 to 1.22)0.194†
Age
 ≥50 versus <501.69 (1.04 to 2.74)0.035*1.89 (0.98 to 3.78)0.051†
BMI
 >25 versus ≤250.78 (0.45 to 1.35)0.376
T stage0.003*0.002*†
 T1Ref.Ref.
 T22.56 (1.03 to 6.34)0.043*2.66 (1.06 to 6.70)0.038*
 T33.00 (1.23 to 7.29)0.015*3.52 (1.43 to 8.71)0.006*
 T45.02 (2.05 to 12.30)<0.001*5.56 (2.23 to 13.82)<0.001*
N stage0.005*0.003*†
 N0Ref.Ref.
 N13.97 (1.52 to 10.34)0.005*4.96 (1.88 to 13.14)0.001*
 N24.01 (1.56 to 10.34)0.004*4.90 (1.87 to 12.79)0.001*
 N36.93 (2.42 to 19.86)<0.001*7.59 (2.60 to 22.12)<0.001*
Chemotherapy
 Yes versus No1.05 (0.63 to 1.75)0.846
IMRT
 Yes versus No0.85 (0.52 to 1.37)0.496
SIRI
 >0.84 versus ≤0.842.96 (1.69 to 5.20)<0.001*2.78 (1.57 to 4.92)<0.001*†
NLR
 >1.85 versus ≤1.852.08 (1.19 to 3.65)0.011*2.03 (1.15 to 3.60)0.015*‡
PLR
 >112 versus ≤1121.82 (1.09 to 3.05)0.023*1.78 (1.05 to 3.00)0.031*§
MLR
 >0.29 versus ≤0.291.83 (1.16 to 2.89)0.010*1.61 (1.01 to 2.55)0.046*¶
  • *represents a statistically significant difference.

  • †The variables (sex, age, T stage, N stage and SIRI) were tested in a multivariate analysis.

  • ‡The variables (sex, age, T stage, N stage and NLR) were tested in a multivariate analysis.

  • §The variables (sex, age, T stage, N stag and PLR) were tested in a multivariate analysis.

  • ¶The variables (sex, age, T stage, N stage and MLR) were tested in a multivariate analysis.

  • BMI, body mass index; IMRT, intensity-modulated radiotherapy; MLR, monocyte lymphocyte ratio; NLR, neutrophil lymphocyte ratio; PLR, platelet lymphocyte ratio; Ref, reference; SIRI, Systemic Inflammation Response Index.