Abstract 8 Table 1

Novel metabolites associated with left ventricular mass index

PathwaySubpathwayMetaboliteWhites1 Blacks1
Beta (SE)P-valueBeta (SE)SE
Amino Acid Glutamate Metabolism Beta-Citrylglutamate 2.20 (0.50) 1.10E-05* 0.84 (0.92) 3.60E-01
Histidine Metabolism1-Methylimidazoleacetate 1.95 (0.47) 4.00E-05* 1.23 (0.80) 1.20E-01
Histidine Metabolism N-Acetylhistidine 2.73 (0.65) 3.00E-05* 1.55 (1.07) 1.50E-01
Methionine, Cysteine, S-Adenosylmethionine, and Taurine Metabolism N-Acetylmethionine 3.73 (0.81) 4.70E-06* 1.69 (1.17) 1.50E-01
Cofactor and Vitamin Tocopherol Metabolism Gamma-CEHC Glucuronide 0.82 (0.20) 4.10E-05* 0.08 (0.12) 5.20E-01
Lipid Sphingolipid Metabolism Sphingomyelin (d17:2/16:0, d18:2/15:0) -4.20 (4.77) 1.70E-05* -4.08 (2.36) 8.80E-02
Nucleotide Purine Metabolism, Adenine Containing N6-Succinyladenosine 1.64 (0.16) 8.90E-06* 0.48 (0.49) 3.20E-01
Xenobiotic Benzoate Metabolism O-Methylcatechol Sulfate 0.67 (0.37) 2.10E-05* 0.23 (0.21) 2.70E-01
  • *Statistically significant p-value (Bonferroni corrected p-value=4.16E-05). 1. Adjusted for age, sex, education, cigarette smoking, alcohol drinking, low density lipoprotein, high density lipoprotein, serum triglycerides, HbA1C, average systolic blood pressure, and body mass index.