Table 3

Metabolic characteristics

Brain tumor survivors (BTS)NHANES III
Reference population
Radiation exposure to the HPA n=60No radiation exposure to the HPA
n=82
n=1878
Median (IQRs)*P value
RE vs no RE
Median (IQRs)†P value vs BTS
Glucose (mg/dL)80 (78, 83)78 (76, 81)0.14
HOMA-IR‡(%)0.93 (0.71, 1.2)*0.78 (0.66, 92)0.03
C-peptide (ng/mL)1.53 (1.24, 1.89)1.37 (1.11, 1.67)0.10
IGF-1 (ng/mL)162 (138, 194)*226 (182, 261)0.01
Adiponectin (μg/mL)13.5 (10.0, 16.7)11.3 (9.8, 13.1)0.39
Leptin (ng/mL)9.3 (5.7, 16.3)9.5 (5.3, 15.3)0.79
Triglycerides (mg/dL)84 (73, 101)†76 (69, 89)†0.0764 (62, 65)<0.001
Non-HDL cholesterol (mg/dL)101 (96, 119)†102 (97, 110)†0.1899 (98, 101)<0.001
HDL cholesterol (mg/dL)50 (44, 54)†50 (48, 54)†0.4256 (55, 56)<0.001
Systolic blood pressure (mm Hg)111 (109, 114)†113 (110, 117)†0.83108.7 (108, 109)<0.001
Diastolic blood pressure (mm Hg)65 (64, 66)†65 (64, 67)†0.3162 (61, 62)<0.001
  • *Significantly different from group not exposed to radiation therapy.

  • †Significantly different from reference NHANES group.

  • ‡Geometric means.

  • HDL, high-density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; HPA, hypothalamus-pituitary-adrenal axis; IGF-1, insulin-like growth factor-1.