Univariate and multivariate survival analysis on CSS in primary ocular B-cell lymphoma from SEER database
| Variable | Univariate analysis | Multivariate analysis | ||
| HR (95% CI) | P values | HR (95% CI) | P values | |
| Age (years) | ||||
| <60 | Reference | Reference | ||
| ≥60 | 3.867 (2.842 to 5.262) | <0.001 | 3.227 (2.359 to 4.416) | <0.001 |
| Race | ||||
| White | Reference | Reference | ||
| Black | 0.468 (0.256 to 0.857) | 0.014 | 0.733 (0.398 to 1.350) | 0.319 |
| Other (American Indian/AK Native, Asian/Pacific Islander) | 0.469 (0.297 to 0.740) | 0.001 | 0.642 (0.405 to 1.018) | 0.060 |
| Gender | ||||
| Female | Reference | |||
| Male | 1.073 (0.846 to 1.361) | 0.561 | ||
| Lymphoma subtypes | ||||
| DLBCL | Reference | Reference | ||
| Follicular lymphoma | 0.306 (0.198 to 0.472) | <0.001 | 0.369 (0.236 to 0.577) | <0.001 |
| MALT lymphoma | 0.168 (0.124 to 0.228) | <0.001 | 0.276 (0.196 to 0.388) | <0.001 |
| Another B-cell lymphoma | 0.469 (0.346 to 0.636) | <0.001 | 0.611 (0.442 to 0.844) | 0.003 |
| Primary site | ||||
| Conjunctiva | Reference | Reference | ||
| Other sites | 3.066 (2.167 to 4.337) | <0.001 | 1.930 (1.349 to 2.762) | <0.001 |
| Laterality | ||||
| Left—origin of primary | Reference | Reference | ||
| Right—origin of primary | 1.157 (0.895 to 1.497) | 0.266 | 1.109 (0.857 to 1.437) | 0.431 |
| Paired site | 1.743 (1.206 to 2.518) | 0.003 | 1.998 (1.379 to 2.896) | <0.001 |
| Radiation | ||||
| No | Reference | Reference | ||
| Yes | 0.506 (0.399 to 0.642) | <0.001 | 0.608 (0.476 to 0.778) | <0.001 |
| Chemotherapy | ||||
| No | Reference | Reference | ||
| Yes | 2.654 (2.092 to 3.368) | <0.001 | 1.440 (1.099 to 1.888) | 0.008 |
| Surgery | ||||
| No | Reference | |||
| Yes | 0.944 (0.741 to 1.202) | 0.639 | ||
| Unknown | 0.567 (0.079 to 4.052) | 0.572 | ||
| Insurance status | ||||
| Uninsured | Reference | |||
| Insured/any Medicaid | 1.338 (0.331 to 5.412) | 0.683 | ||
| Insurance status unknown | 1.625 (0.403 to 6.556) | 0.495 | ||
| Marital status | ||||
| Never married | Reference | |||
| Married | 1.317 (0.885 to 1.959) | 0.174 | ||
| Ever married (divorce, separated, and widowed) | 1.531 (0.990 to 2.367) | 0.055 | ||
| Unknown | 1.306 (0.769 to 2.218) | 0.323 | ||
CSS, cancer-specific survival; DLBCL, diffuse large B-cell lymphoma; MALT, mucosa-associated lymphoid tissue lymphoma; SEER, Surveillance, Epidemiology, and End Results.