Abstract 28 Table 1 Highlights the variable phamacokinetics of different opioids and the limited data about rates of NAS following exposure

DrugHalf-life (PO)Incidence of NAS with intra-uterine exposureTime to onset of NAS symptomsTime to peak withdrawalDuration of withdrawal
Buprenorphine 24–42 hour 7%–67% 36–60 hour 72 hour >/=28 days
Buprenorphine/Naloxone 24–42 hour/2–12 hour 40% 36–60 hour 72 hour >/=28 days
Methadone 9–87 hour 13%–94% 36–72 hour 96–144 hour >/=30 days
Heroin <30 min 18%–80% 8–48 hour 36–72 hour 8–10 days
Hydrocodone 4 hour 5%–20% 8–12 hour 36–72 hour 10–30 days
Oxycodone 3–5 hour 5%–20% 8–12 hour 36–72 hour 10–30 days
Morphine 2–4 hour 5%–20% 8–12 hour 36–72 hour 10–30 days