Abstract 111 Table 1

Short-term efficacy and safety profiles of intravenous continuous glucagon infusion in 26 neonates

Intravenous continuous glucagon infusionP value
VariablesBefore (12 hour period)During (24 hour period)After (24 hour period)Before vs duringBefore vs after
Lowest blood glucose (mg/dl) 26±10 61±13 68±21 <0.001 <0.001
Maximum intravenous fluid glucose infusion rates (mg/kg/min) 7.7±2.3 7.5±2.6 4.9±3.2 0.73 0.001
Number of hypoglycemic episodes, n 4±2 1±1.4 1±2 <0.001 <0.001
Intravenous fluid volume (ml/kg/day) 85±24 77±24 50±31 0.22 <0.001
Hyponatremia (serum sodium<135), n (%) 10(38) 7 (27) 4 (15) 0.37 0.06
Thrombocytopenia (platelets<100, 000/ml), n (%) 5 (19) 5 (19) 3 (11) >0.99 0.42
Metabolic acidosis (serum bicarbonate<18 mEq/L), n (%) 3 (11) 1 (3) 2 (8) 0.3 0.63