Abstract 246 Table 1

Studies Summarizing the Association Between Long-term Use of PPIs and Osteopenia/Bone Fractures

Author, yearStudy typeAge rangeDuration of PPI useDefinition of subjects (total N) and% effectedDefinition of control group (total N) and% effectedOdds ratioP-value
Lewis JR, 2014 Longitudinal prospective cohort Over 70 years 6 years Osteopenic fractures in 17 of 120 (14.2%) of PPI Users Osteopenic fractures in 77 of 905 (8.5%) of Non-PPI Users 1.78 0.046
Arj A, 2016 Cross-sectional 20–45 years 2 years Femur Osteoporosis in 5 of 40 (12.5%) of PPI Users
Lumber Osteoporosis in 4 of 40 (10%) of PPI Users
Femur Osteoporosis in 0 of 40 (0%) of Non-PPI Users
Lumbar Osteoporosis in 1 of 40 (2.5%) of Non-PPI Users
0.04 for femur
0.28 for lumbar
Targownik LE, 2008 National Database Over 50 years 7 years 32 of 1830 (1.7%) with Osteopenic fractures used PPI more than 7 years 49 of 5482 (0.9%) matched controls with Osteopenic fractures did not use PPI 1.92 0.011
Yang YX, 2006 General Practice Research Database Over 50 years 1 year
2 years
3 years
4 years
534 of 13 556 (3.9%) of PPI users had hip fractures 3228 of 1 35 386 (2.8%) of non-PPI users had hip fractures 1.4 <0.05
Ding J, 2014 Retrospective cohort Over 65 years Index date to fracture event Incidence of fracture was 8.7% in 1604 PPI users Incidence of fracture was 5% in 23 672 non-PPI users 1.28 0.003
Van der Hoorn, 2015 Longitudinal National Pharmaceutical Database Over 75 years 7 years 827 of 2328 (36%) of PPI users used medication for osteopenia 550 of 2104 (26%) of non-PPI users used medication for osteopenia 1.29 0.006
Jacob L, 2016 Case-control 60–90 years 5 years 21.3% of 3092 of women with osteoporosis took PPIs 13.7% of 3092 women with osteoporosis did not take PPIs 1.62 0.001
Targownik LE, 2010 Manitoba Bone Mineral Density (BMD) Database Over 60 years 5 years 110 patients had a BMD measurement after PPI use of 2–3 years Same 110 patients had a baseline BMD measurement Change in bone mineral density −0.08% lumbar
−0.09% hip
>0.2
Targownik LE, 2017 PPI users identified in Manitoba Health Registry and surveyed Over 60 years 5 years 52 PPI users with a Mean DXA score of 0.13 g/cm2 52 non-PPI users with a Mean DXA score of 0.12 g/cm2 >0.2