PT  - JOURNAL ARTICLE
AU  - Bjørbæk, Christian
TI  - Central Leptin Receptor Action and Resistance in Obesity
AID  - 10.2310/JIM.0b013e3181bb0d49
DP  - 2009 Oct 01
TA  - Journal of Investigative Medicine
PG  - 789--794
VI  - 57
IP  - 7
4099  - http://jim.bmj.com/content/57/7/789.short
4100  - http://jim.bmj.com/content/57/7/789.full
SO  - J Investig Med2009 Oct 01; 57
AB  - The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.