PT  - JOURNAL ARTICLE
AU  - Kuloğlu, Osman
AU  - Gür, Mustafa
AU  - Şeker, Taner
AU  - Kalkan, Gülhan Yüksel
AU  - Şahin, Durmuş Yıldıray
AU  - Tanboğa, İbrahim Halil
AU  - Koyunsever, Nermin Yıldız
AU  - Harbalıoğlu, Hazar
AU  - Türkoğlu, Caner
AU  - Akyol, Selahattin
AU  - Elbasan, Zafer
AU  - Acele, Armağan
AU  - Çaylı, Murat
TI  - Serum 25-Hydroxyvitamin D Level Is Associated With Arterial Stiffness, Left Ventricle Hypertrophy, and Inflammation in Newly Diagnosed Hypertension
AID  - 10.2310/JIM.0b013e31829a82bc
DP  - 2013 Aug 01
TA  - Journal of Investigative Medicine
PG  - 989--994
VI  - 61
IP  - 6
4099  - http://jim.bmj.com/content/61/6/989.short
4100  - http://jim.bmj.com/content/61/6/989.full
SO  - J Investig Med2013 Aug 01; 61
AB  - Objectives Vitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis, and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy (LVH) in hypertensive patients. We aimed to evaluate the association between serum vitamin D with arterial stiffness and LVH in patients with hypertension.Methods We studied 133 patients with newly diagnosed hypertension [mean (SD) age, 62.9 (10.6) years]. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph ARCsolver algorithm. Left ventricular mass index (LVMI) was determined according to Deverux formula. The patients were divided into the following 2 groups according to serum vitamin D level: vitamin Dlow group with less than 20 ng/mL and vitamin Dhigh group with greater than or equal to 20 ng/mL.Results The highest PWV, high-sensitivity C reactive protein, and LVMI values were observed in vitamin Dlow group compared with vitamin Dhigh group. Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β = −0.235, P = 0.002) and PWV (β = −0.432, P < 0.001). Adjustment for age, sex, parathyroid hormone level, body surface area, and mean blood pressure did not modify these associations. Vitamin D level was also independently associated with high-sensitivity C reactive protein (β = −0.143, P = 0.047). However, adjustment for parathyroid hormone level or body surface area and mean blood pressure attenuate this association.Conclusions Serum 25-hyroxyvitamin D is independently related with arterial stiffness, LVH, and inflammation. Vitamin D may play a role on pathogenesis of arterial stiffness and LVH in patient with newly diagnosed hypertension.