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Prevalence and determinants of severity of uremic pruritus in hemodialysis patients: a multicentric study
  1. Amany M Abdallah1,
  2. Samaa M Elsheikh2,
  3. Rasha A ElBarbary3
  1. 1Internal Medicine Department, Al-Azhar University, Cairo, Egypt
  2. 2Dermatology Department, Alexandria University, Alexandria, Egypt
  3. 3Dermatology and Venereology Department, Al-Azhar University, Cairo, Egypt
  1. Correspondence to Dr Amany M Abdallah, Internal Medicine Department, Al-Azhar University, Cairo 11651, Egypt; dr_amanyabdallah{at}yahoo.com

Abstract

Uremic pruritus (UP) is a common and distressing symptom in patients with advanced or end-stage renal disease under hemodialysis (HD). The present multicentric study aimed to identify prevalence and determinants of severity of UP among Egyptian patients. Performed investigations included serum urea, creatinine, calcium, phosphorus, parathormone, ferritin and liver enzymes. Pruritus was evaluated using the visual analog scale. The study included 295 patients on maintenance HD. They comprised 151 patients (51.2%) with UP. Independent predictors of UP included associated hypertension (OR: 0.48, 95% CI 0.28 to 0.83, p=0.008), higher calcium levels (OR: 1.29, 95% CI 1.02 to 1.62, p=0.032), higher phosphorus levels (OR: 1.18, 95% CI 1.02 to 1.37, p=0.03) and higher high-sensitivity C-reactive protein (hsCRP) levels (OR: 1.0, 95% CI 1.0 to 1.01, p=0.049). Independent predictors of significant UP included longer HD duration (OR: 1.23, 95% CI 1.1 to 1.38, p<0.001), lack of vitamin D supplementation (OR: 3.71, 95% CI 1.03 to 13.4, p=0.045), lower albumin levels (OR: 0.32, 95% CI 0.14 to 0.74, p=0.008) and higher hsCRP levels (OR (CRP): 1.02 (1.0–1.03), p=0.011). In conclusion, UP is fairly common among Egyptian HD patients. Independent predictors of UP severity include longer HD duration, lack of vitamin D supplementation, lower albumin levels and higher hsCRP levels.

  • Chronic Disease
  • Kidney Diseases

Data availability statement

Data are available upon reasonable request.

http://dx.doi.org/10.1136/jim-2022-002360

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    Data availability statement

    Data are available upon reasonable request.

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    Footnotes

    • Contributors AMA and RAE contributed to this work through study planning, conception and design. SME contributed to this work through data acquisition and analysis and manuscript drafting. AMA and RAE revised and approved the manuscript. AMA is responsible for the overall content as guarantor.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.