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Evaluation of dynamic thiol-disulfide homeostasis and ischemia-modified albumin levels in patients with chronic lymphocytic leukemia
  1. Huseyin Erdal1,
  2. Rafiye Ciftciler2,
  3. Sibel Cigdem Tuncer3,
  4. Oguzhan Özcan4
  1. 1Medical Genetics, Aksaray University, Aksaray, Turkey
  2. 2Hematology, Aksaray University, Aksaray, Turkey
  3. 3Biochemistry, Aksaray University, Aksaray, Turkey
  4. 4Biochemistry, Hatay Mustafa Kemal University, Hatay, Turkey
  1. Correspondence to Dr Huseyin Erdal, Medical Genetics, Aksaray University, Aksaray, Merkez, Turkey; herdalyfa{at}


This is the first study to evaluate both the dynamic thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels in patients with chronic lymphocytic leukemia (CLL). Twenty-nine patients with CLL and 20 controls were included in the study. The dynamic thiol-disulfide balance was determined by the newly developed colorimetric method by Erel. IMA levels were determined by the cobalt binding test. We found that total antioxidant status levels were lower while total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher in patients with CLL than controls. Moreover, native and total thiol levels were found to be statistically significant between the study and control groups (p<0.001), whereas no statistically significant difference was noted for IMA levels (p=0.365). A negative correlation was observed between native and total thiol levels, leukocyte, lymphocyte, and TOS. Total bilirubin showed positive correlation with direct bilirubin and alkaline phosphatase. In addition, IMA levels showed a positive correlation with OSI. This study highlights measurement of native and total thiol and IMA levels in patients with CLL for the first time. Dynamic thiol-disulfide homeostasis may contribute in the pathophysiological mechanism, and follow-up to disease in patients with CLL.

  • oxidants
  • leukemia
  • hematology
  • hematologic diseases

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  • Contributors Conception and design of the research: HE. Acquisition of data: HE, RC, OÖ, SCT. Analysis and interpretation of data: HE, RC, OÖ. Statistical analysis: HE. Drafting the manuscript: HE. Revision of manuscript for important intellectual content: HE, RC, OÖ, SCT. Guarantor: HE.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.