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Burden of arrhythmias and predictors of mortality among multiple myeloma patients with arrhythmias
  1. Omotola Balogun1,
  2. Inimfon Jackson1,
  3. Mosunmoluwa Oyenuga2,
  4. Abayomi Oyenuga3,
  5. Aniekeme Etuk4,
  6. Nsikak Jackson5
  1. 1Department of Medicine, Albert Einstein Healthcare Network, Philadelphia, Pennsylvania, USA
  2. 2Department of Internal Medicine, SSM St Mary's Health Center, St Louis, Missouri, USA
  3. 3Department of Medicine, University of Minnesota System, Minneapolis, Minnesota, USA
  4. 4Department of Internal Medicine, Thomas Hospital, Fairhope, Alabama, USA
  5. 5Department of Management, Policy and Community Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA
  1. Correspondence to Dr Inimfon Jackson, Albert Einstein Healthcare Network, Philadelphia, Pennsylvania, USA; Jackso32{at}einstein.edu

Abstract

Arrhythmias are a major cardiac complication reported among patients with multiple myeloma (MM), but these have not been further characterized in this population. We explored the prevalence of arrhythmias and examined the predictors of mortality among patients with MM with arrhythmias. The National Inpatient Sample data collected between 2016 and 2018 were used to conduct retrospective analyses. Multivariable logistic regression analyses were done to examine the predictors of mortality among patients with MM with arrhythmias. 16.9% of patients with MM reported a diagnosis of any arrhythmias and 70.7% of these were atrial fibrillation. Patients aged 70 years and above had 21% lower odds (adjusted OR (AOR): 0.79; 95% CI: 0.68 to 0.92) of inpatient mortality relative to younger patients. Those in the non-Hispanic black, Hispanic, and non-Hispanic other category were 1.38 (95% CI: 1.16 to 1.64), 1.53 (95% CI: 1.19 to 1.97), and 1.69 (95% CI: 1.29 to 2.21) times more likely to die during hospitalization compared with their counterparts who were non-Hispanic whites. Relative to patients with MM who were on Medicare, those on private (AOR: 1.28; 95% CI: 1.06 to 1.54) and other insurance types (AOR: 1.78; 95% CI: 1.23 to 2.58) had higher odds of mortality. Other predictors of inpatient mortality were elective admission (AOR: 0.67; 95% CI: 0.52 to 0.85) and Charlson comorbidity indices between 5–7 (AOR: 1.23; 95% CI: 1.07 to 1.41) and ≥8 (AOR: 1.45; 95% CI: 1.21 to 1.73) compared with comorbidity indices between 0 and 4. Our study adds to the body of knowledge on the need for proper diagnosis and management of cardiac arrhythmias in patients with MM. Research is needed to further assess the time of arrhythmia diagnosis and its impact on health outcomes among patients with MM.

  • arrhythmias, cardiac
  • inpatients

Data availability statement

Data are available in a public, open access repository. All data supporting these study findings are available on the Agency for Healthcare Research and Quality website at https://www.hcup-us.ahrq.gov/db/nation/nis/nisdbdocumentation.jsp.

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Data availability statement

Data are available in a public, open access repository. All data supporting these study findings are available on the Agency for Healthcare Research and Quality website at https://www.hcup-us.ahrq.gov/db/nation/nis/nisdbdocumentation.jsp.

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Footnotes

  • Contributors OB and IJ contributed equally to this paper. IJ is responsible for the overall content as the guarantor. OB and IJ conceptualized the study. OB, IJ, and MO contributed to acquisition, analysis, interpretation of the data, and drafted the manuscript. OB, IJ, MO, AO, AE, and NJ critically reviewed the manuscript for intellectual content and revised the manuscript. All authors approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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