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Altered degree centrality in patients with non-neuropsychiatric systemic lupus erythematosus: a resting-state fMRI study
  1. Xiaolou Li1,
  2. Peng Zhang1,
  3. Wensu Zhou1,
  4. Yuan Li2,
  5. Zhongru Sun2,
  6. Jinhua Chen2,
  7. Jianguo Xia2,
  8. Hongmei Zou3
  1. 1Graduate School Of Dalian Medical University, Dalian, Liaoning, China
  2. 2Department of Radiology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
  3. 3Department of Rheumatology and Immunology, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, China
  1. Correspondence to Dr Jianguo Xia, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu 225300, China; 896622827{at}qq.com; Dr Jinhua Chen; js.tz.cjh{at}163.com; Dr Hongmei Zou; shjxct{at}163.com

Abstract

This study used a voxel-wise degree centrality (DC) method to evaluate differences in brain activity between patients with non-neuropsychiatric systemic lupus erythematosus (non-NP-SLE) and healthy controls (HCs) and to assess the relationship of DC values with clinical and neuropsychological data. Thirty-two female patients with non-NP-SLE and 28 well-matched HCs were recruited and underwent resting-state functional MRI. Differences in spontaneous brain activity between the two groups were evaluated using a DC method. Correlations between the altered DC values of specific brain regions and clinical and neuropsychological data were explored using Spearman correlation analysis. Receiver operating characteristics curve analysis was applied to differences in DC values in specific brain regions to determine their value in distinguishing patients with non-NP-SLE from HCs. Compared with HCs, DC values in patients with non-NP-SLE were significantly lower in the bilateral postcentral gyrus and the orbital part of the left superior frontal gyrus (LFMO). DC values in some specific brain regions such as the bilateral postcentral gyrus and the LFMO correlated with Mini-Mental State Examination scores in both subject groups. In patients with non-NP-SLE, DC values of the right postcentral gyrus were positively correlated with IgA levels, and DC values of the LFMO were positively correlated with Systemic Lupus Erythematosus Disease Activity Index 2000 scores, as well as IgA levels. Receiver operating characteristics curve analysis revealed that the DC values of specific brain regions can be used to differentiate patients with non-NP-SLE from HCs.

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Data availability statement

Data are available upon reasonable request.

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Data availability statement

Data are available upon reasonable request.

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Footnotes

  • Contributors JX acts as guarantor. JX, JC, and HZ designed the study and revised the manuscript. XL, PZ, WZ, YL, ZS, and JC performed the experiments and collected the data. PZ, WZ, YL, and ZS analyzed the data. XL drafted the manuscript. All authors reviewed and edited the manuscript and approved the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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