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Systemic amyloidosis is a syndrome of protean manifestations and many pathophysiologies, united by the histopathologic demonstration of extracellular deposition of Congo red-positive fibrillar material that shows apple green birefringence under polarized light microscopy.1 Its clinical features vary depending on the site of amyloid deposition and the particular protein of which amyloid is comprised. Symptomatic deposition of amyloid may involve the heart, the liver, the kidneys, the stomach and intestines; the central, peripheral, or autonomic nervous systems; the lungs or upper airway; or the skin.1 Familial Mediterranean fever is an autosomal recessive disorder of amyloid deposition.2
Since it can present in so many …
Contributors RTM is the sole author.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
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