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Relationship between cerebral venous sinus thrombosis and intracranial arteritis during pregnancy and post partum
  1. Xiurong Li,
  2. Jianan Dong,
  3. Yaping Sun,
  4. Qing Li,
  5. Li Shi
  1. Department of Obstetrics and Gynecology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
  1. Correspondence to Dr Li Shi, Department of Obstetrics and Gynecology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China; shili11927{at}163.com

Abstract

Our study was conducted to explore the relationship between cerebral venous sinus thrombosis (CVST) and intracranial arteritis during the time of pregnancy as well as puerperium. The current retrospective case study involved a total of 153 patients with pregnancy-related CVST. CVST was diagnosed mainly based on clinical manifestations and imaging results. Detailed information on demographics, risk factors (excluding intracranial arteritis), and pregnancy outcomes was systematically recorded. The average age of patients diagnosed with CVST was 28.67±3.54 years old. Among these patients, there were 62 cases of puerperal CVST and 91 cases of pregnancy-related CVST. The clinical manifestations of patients with CVST included headache in 55 cases (35.95%), symptomatic seizures in 26 cases (16.99%), symptomatic limb weakness in 22 cases (14.38%), symptomatic nausea/vomiting in 18 cases (11.76%), symptomatic disturbance of consciousness in 15 cases (9.80%), symptomatic blurred vision in 10 cases (6.54%), and symptomatic fever in 7 cases (4.58%). A proportion of patients reported higher abnormal cerebrospinal fluid pressure (98.28%), white cell count (79.31%), total cholesterol (71.55%) and low-density lipoprotein (62.93%) (p<0.01). The proportion of intracranial arteritis lesions and CVST lesions was high, including 51 cases (43.97%) on the left side and 31 cases (26.72%) on the right side. Bilateral CVST lesions occurred in 13 cases (11.20%) of unilateral intracranial arteritis lesions, and bilateral intracranial arteritis lesions occurred in 16 cases (13.79%) of unilateral CVST lesions. In summary, CVST indicates a potential positive link to intracranial arteritis at the time of pregnancy and puerperium.

  • pregnancy

Data availability statement

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Data availability statement

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Footnotes

  • Contributors XL and LS contributed to the conception and design of the study. XL and JD performed the experiments and collected and analyzed the data. JD and YS wrote the manuscript. All authors reviewed and approved the final version of the manuscript.

  • Funding This study was supported by Hebei Province Medical Science Research Key Project (no.20160175).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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