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Prevalence and predictors of colonoscopic findings in patients with autoimmune gastritis
  1. Emra Asfuroglu Kalkan1,
  2. Cagdas Kalkan2,
  3. Mesut Gumussoy3,
  4. Ozge Gucbey1,
  5. Irfan Soykan3
  1. 1Departments of Internal Medicine and Gastroenterology, Ministry of Health, Ankara City Hospital, Ankara, Turkey
  2. 2Gastroenterology, Ankara City Hospital, Ankara, Turkey
  3. 3Division of Gastroenterology, Ibni Sina Hospital, Ankara University Faculty of Medicine, Ankara, Turkey
  1. Correspondence to Professor Irfan Soykan, Division of Gastroenterology, Ibni Sina Hospital, Ankara University Faculty of Medicine, Ankara 06100, Turkey; isoykan{at}medicine.ankara.edu.tr

Abstract

The clinical spectrum of autoimmune gastritis is silent in the early stages of the disease and no specific symptom is related to this entity. Although gastroscopic findings of this entity are well defined, data regarding colonoscopic findings are limited. The aims of this study were to determine the prevalence of colonoscopic findings and to explore factors that might affect these findings. This is a retrospective chart review of patients with autoimmune gastritis (n=240). Data regarding colonoscopic findings, serum gastrin and chromogranin A (CgA) levels and gastric histopathological results were extracted and compared with 550 patients positive for Helicobacter pylori and gastric atrophy. Control subjects had colonoscopy and gastroscopy with biopsies. Colorectal lesions were observed in 64 (26.6%) of patients with autoimmune gastritis and 36 (6.6%) patients had colorectal lesions in the control group (p<0.001). Serum gastrin (OR: 8.59, 95% CI 1.72 to 25.07, p<0.001) and CgA levels (OR: 6.79, 95% CI 0.41 to 27.26, p<0.001) were found as factors affecting the presence of colorectal carcinoma. Serum gastrin and CgA levels were also found as predictors for the presence of colorectal adenomas. There is a higher prevalence of colorectal neoplastic lesions in patients with autoimmune gastritis. Serum gastrin and CgA levels were found to be determinants of colorectal neoplastic lesions observed in patients. In the workup of these patients, serum gastrin and CgA levels may guide physicians for the demonstration of colorectal neoplastic lesions.

  • colonoscopy
  • autoimmune diseases
  • colorectal neoplasms

Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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Data availability statement

All data relevant to the study are included in the article or uploaded as supplementary information.

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Footnotes

  • Contributors EAK, MG, OG: acquisition of data. CK: analysis and interpretation of data. IS: study conceptualization, writing and editing of this work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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