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Tumor invasive ability of papillary thyroid carcinomas is not conferred by acquired gene mutations
  1. Mengying Tong1,
  2. Shuang Li2,
  3. Yulong Li3,
  4. Ying Li3,
  5. Yue Feng1,
  6. Ying Che1
  1. 1Department of Ultrasound, First Affiliated Hospital of Dalian Medical University, Dalian, China
  2. 2Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, China
  3. 3Center of Genome and Personalized Medicine, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, China
  1. Correspondence to Dr Ying Che, Department of Ultrasound, First Affiliated Hospital of Dalian Medical University, Dalian, China; cheying{at}; Dr Shuang Li, Department of General Surgery, First Affiliated Hospital of Dalian Medical University, Dalian, China; shuangli{at}


Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The ability to predict whether a carcinoma would exhibit invasive ability in patients with PTC is important and has clinical implications for the selection of therapeutic strategies. Although several studies have focused on the genetic characterization of invasive cancer cells, the factors critical to the origination of invasive cancer cells are still unclear. This study aimed to determine whether genomic mutations contribute to the acquisition of the tumor invasion phenotype and to investigate the genetic features of invasive cancer cells in patients with PTC. We performed customized 48-gene deep exon sequencing in samples obtained from 88 patients with PTC via fine needle aspiration; the results revealed that no genetic changes were specifically associated with the tumor aggressiveness phenotype. Our results indicate that genetic mutations do not cause indolent PTCs to become invasive.

  • thyroid neoplasms
  • mutation

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  • Contributors MT collected the samples, performed the experiments, analyzed the data and wrote the paper. Yulong Li, Ying Li and YF carried out additional analyses and supported the study. YC and SL jointly designed, oversaw and directed the study.

  • Funding This work was supported by the National Natural Science Foundation of China (82003143 to MT and 82000075 to SL) and Liaoning Province Education Foundation (LZ2020070 to MT).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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