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Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19
  1. Huilin Fang,
  2. Qiaomei Liu,
  3. Maomao Xi,
  4. Di Xiong,
  5. Jing He,
  6. Pengcheng Luo,
  7. Zhanghua Li
  1. Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China
  1. Correspondence to Dr Zhanghua Li, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan 430074, China; lzh999999{at}


The study aimed to compare the clinical characteristics and outcomes of patients with different types (ordinary, severe, and critical) of COVID-19. A total of 1280 patients diagnosed with COVID-19 were retrospectively studied, including 793 ordinary patients, 363 severe patients and 124 critical patients. The impact of comorbidities on prognosis in ordinary, severe, and critical patients were compared and analyzed. The most common comorbidities were hypertension (33.0%), followed by diabetes (14.4%). The length of hospital stay and time from the onset to discharge were significantly longer in ordinary patients with comorbidities compared with those without comorbidities. Critical patients with comorbidities had significantly lower cure rate (19.3% vs 38.9%, p<0.05) and significantly higher mortality rate (53.4% vs 33.3%, p<0.05) compared with those without comorbidities. The time from onset to discharge was significantly longer in ordinary patients with hypertension compared with those without hypertension. The mortality rate of critical patients with diabetes was higher than that of patients without diabetes (71.4% vs 42.7%, p<0.05). Men had a significantly increased risk of death than women (OR=4.395, 95% CI 1.896 to 10.185, p<0.05); patients with diabetes had higher risk of death (OR=3.542, 95% CI 1.167 to 10.750, p<0.05). Comorbidities prolonged treatment time in ordinary patients, increased the mortality rate and reduced the cure rate of critical patients; hypertension and diabetes may be important factors affecting the clinical course and prognosis of ordinary and critical patients, respectively.

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  • Contributors ZL and PL designed the study and revised the manuscript. JH and HF, QL, MX, DX and JH collated the data and carried out the data analyses. HF wrote the main manuscript text. All authors have read and approved the final submitted manuscript.

  • Funding This work was supported by the Health Family Planning Research Fund of Wuhan City (grant number WX18M01), the Wuhan City ‘Huanghe Talent’ Program, and the Wuhan Application Foundation Frontier Project (grant number 2019020701011471).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study is approved by the ethics committee of Wuhan Third Hospital, Tongren Hospital of Wuhan University (KY2020-014). Informed consent was waived due to the retrospective nature of this study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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