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Original research
Coronary artery lesion risk and mediating mechanism in children with complete and incomplete Kawasaki disease
  1. Hongying Shi1,2,
  2. Huixian Qiu2,3,
  3. Zengyou Jin4,
  4. Chen Li2,3,
  5. Xinjun Yang1,
  6. Chenping Huang1,
  7. Rongzhou Wu2,3,
  8. Guihua Zhuang5,
  9. Maoping Chu2,3
  1. 1 Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
  2. 2 Institute of Cardiovascular Development and Translation Medicine, Wenzhou Medical University, Wenzhou, China
  3. 3 Children’s Heart Center, Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
  4. 4 Department of Pediatric Cardiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  5. 5 Department of Public Health, Xi’an Jiaotong University, Xi’an, China
  1. Correspondence to Dr Maoping Chu, Institute of Cardiovascular Development and Translation Medicine, Wenzhou Medical University, Wenzhou 325000, China; chmping{at}126.com

Abstract

To compare the risk of coronary artery lesions (CAL) in children with complete and incomplete Kawasaki disease (KD) before and after immunoglobulin therapy and explore the mediation mechanisms underlying this association. All patients with KD admitted to the Wenzhou Medical University affiliated Yuying Children’s Hospital were divided into complete and incomplete KD groups. The independent effect of KD type on the risk of CAL and the intermediate effect of admission time on the association between KD type and CAL were assessed. The incidence of CAL in children with incomplete KD was higher than that in children with complete KD (33.9% vs 23.0%, p<0.001), and was also higher before therapy (27.5% vs 14.8%). Among children without CAL before therapy, there was no statistical difference in the incidence of CAL after treatment between the two groups. Mediation analysis found that the mediating effect of admission time was 1.07 (95% C: 1.01 to 1.13), and the direct effect of KD type on CAL was 1.59 (95% CI 1.17 to 2.16); proportion mediated was 15.71%. In conclusion, the risk of CAL among patients with incomplete KD was higher than that for complete KD, especially before therapy. In patients without CAL before treatment, the risk of CAL after treatment was equivalent for the two groups. Delayed admission may be one of the important mediating mechanisms for the higher risk of CAL in incomplete KD children.

  • cardiology
  • risk

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Footnotes

  • Contributors MC and HS designed the study. HQ, ZJ, CL and XY conducted the study. HS analyzed the data. CH, RW and GZ interpreted the results and HS wrote the manuscript. All authors reviewed and approved the manuscript.

  • Funding This study was supported by the project of risk factors and scoring system for predicting the risk of coronary artery lesions in Kawasaki disease, National Natural Science Foundation, China (81502893), the project of study on the mediation mechanism between the type of Kawasaki Disease and Coronary artery lesions from Zhejiang Province Science and Technology Agency (LY19H260004) and the project of development of scoring system for prognosis prediction among Kawasaki disease patients from Zhejiang Province Science and Technology Agency (2014C33160).

  • Competing interests None declared.

  • Ethics approval The study was conducted according to the principles of the Declaration of Helsinki and approved by the Wenzhou Medical University affiliated Yuying Children’s Hospital’s Research Ethics Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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