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Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus
  1. Ali Sobhy1,
  2. Mohammed Fakhry M.2,
  3. Haitham A Azeem3,
  4. Ahmed M Ashmawy4,
  5. Hamed Omar Khalifa5
  1. 1Clinical Pathology Department., Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
  2. 2Gastroenterology and Hepatology Department, Faculty of Medicine., Al-Azhar University, Assiut.
  3. 3Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
  4. 4Internal Medicine Department, Faculty of Medicine, Assiut University, Assiut, Egypt
  5. 5Public Health andCommunity Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
  1. Correspondence to Dr Ali Sobhy, Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Assiut branch; dralisobhy{at}azhar.edu.eg

Abstract

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

  • liver cirrhosis

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Footnotes

  • Contributors HOK and HAA were responsible for study design and data analysis. ASMH was responsible for study design, practical part, data analysis and interpretation, and manuscript drafting. MFM and AMA were responsible for planning and conduct of the work. All authors revised the article for important intellectual content, reviewed and approved the final version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study was approved by the local ethical committee (Al-Azhar University Hospitals).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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