Article Text

PDF
Plasma haptoglobin level can augment NT-proBNP to predict poor outcome in patients with severe acute decompensated heart failure
  1. Dai-Yin Lu1,2,
  2. Chih-Pei Lin3,4,
  3. Cheng-Hsueh Wu2,5,
  4. Tsai-Mu Cheng6,
  5. Ju-Pin Pan1,2
  1. 1Divisionof Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
  2. 2Schoolof Medicine, National Yang-Ming University, Taipei, Taiwan, ROC
  3. 3Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei, Taiwan, ROC
  4. 4Section of Central Laboratory, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
  5. 5Department of Critical Care, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
  6. 6Graduate Institute of Translational Medicine, College of Medicine and Technology Taipei Medical University, Taipei, Taiwan, ROC
  1. Correspondence to Dr Ju-Pin Pan, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan, ROC; jppan{at}vghtpe.gov.tw

Abstract

To evaluate the use of plasma haptoglobin (Hp) levels and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in predicting survival in patients with severe acute decompensated heart failure (AHF). Management of AHF is challenging. Identifying markers associated with patient prognosis in this disease is clinically important. In this prospective observational study, plasma Hp and NT-proBNP levels were measured. Receiver operating characteristic (ROC) curves were used to identify cut-offs of Hp and NT-proBNP with the greatest specificity and sensitivity for predicting overall survival and cardiovascular-related survival. The cut-off values were tested in patients with AHF (n=41). The cut-off value with the greatest specificity and sensitivity with respect to overall survival and for cardiovascular-related survival for Hp was 177. 1 ng/mL for both outcomes and for NT-proBNP was 34 246.0 pg/mL and 11 848.5 ng/mL, respectively. Using these cut-off values, this study found that patients with lower baseline Hp levels (<177. 1 ng/mL) or higher baseline NT-proBNP (≥34 246 pg/mL) were more likely to have shorter overall survival. Similarly, patients with <177. 1 ng/mL of Hp and ≥11 848.5 pg/mL of NT-proBNP had the highest risk of death related to cardiovascular disease. Our findings indicate that Hp and NT-proBNP using specific cut-off values for AHF can be used to determine risk of survival in these patients.

  • haptoglobin
  • acute decompensated heart failure
  • pro B-type natriuretic peptide
  • overall survival
  • outcome prediction
  • NYHA functional classification

Statistics from Altmetric.com

Footnotes

  • Contributors D-YL: acquisition of data; analysis and interpretation of data; drafting of the manuscript; final approval of the manuscript; clinical studies. C-PL: conception and design; analysis and interpretation of data; drafting of the manuscript; experimental studies. T-MC: conception and design; analysis and interpretation of data; drafting of the manuscript; experimental studies. C-HW: acquisition of data; drafting of the manuscript; final approval of the manuscript; clinical studies. J-PP: conception and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; final approval of the manuscript; guarantor of integrity of the entire study; statistical analysis; definition of intellectual content; literature research; clinical studies; experimental studies; obtaining funding; administrative, technical or material support; supervision; critical revision of the manuscript.

  • Funding This work was supported by the Research Foundation of Cardiovascular Medicine (103-01-003 to J-PP).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This study was approved by the Institutional Review Board of Taipei Veterans General Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.