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Case–control study examining the association between allopurinol use and ischemic cerebrovascular disease
  1. Shih-Wei Lai1,2,
  2. Cheng-Li Lin1,3,
  3. Kuan-Fu Liao4,5
  1. 1College of Medicine, China Medical University, Taichung, Taiwan
  2. 2Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
  3. 3Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  4. 4College of Medicine, Tzu Chi University, Hualien, Taiwan
  5. 5Division of Hepatogastroenterology, Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan
  1. Correspondence to Dr. Kuan-Fu Liao; kuanfuliaog{at}gmail.com

Abstract

Few studies focus on the relationship between allopurinol and ischemic cerebrovascular disease. The goal of the study was to investigate the association of long-term therapy of allopurinol with the first-time attack of ischemic cerebrovascular disease in Taiwan. We performed a case–control study using the database of the Taiwan National Health Insurance Program. The case group included 14,937 subjects aged 20–84 years with the first-time attack of ischemic cerebrovascular disease from 2000 to 2013. The control group included 14,937 sex-matched and age-matched subjects aged 20–84 years without any type of cerebrovascular disease. Ever use of allopurinol was defined as subjects who had at least a prescription for allopurinol before the index date. The OR and the 95% CI for ischemic cerebrovascular disease associated with allopurinol use were measured by the multivariable logistic regression model. The adjusted OR of ischemic cerebrovascular disease was 0.992 (95% CI 0.989 to 0.996) for subjects with increasing cumulative duration of allopurinol use for every 1 month, compared with never use. In a further analysis, the adjusted OR of ischemic cerebrovascular disease was 0.74 (95% CI 0.57 to 0.96) for cumulative duration of allopurinol use >3 years, compared with never use. Our findings suggest that lone-term therapy of allopurinol >3 years is associated with decreased risk of the first-time attack of ischemic cerebrovascular disease, compared with no allopurinol therapy.

  • cardiovascular diseases

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Footnotes

  • Contributors SWL contributed to the conception of the article, initiated the draft of the article, and revised the article. CLL and KFL conducted data analysis and participated in data interpretation.

  • Funding This study was supported in part by the Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004) and China Medical University Hospital (DMR-107-192).

  • Disclaimer The funding agencies did not influence the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval This study was approved by the Research Ethics Committee of China Medical University and Hospital in Taiwan (CMUH-104-REC2-115).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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