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Original research
Study on the influence of pregnancy-induced hypertension on neonatal birth weight
  1. Fangliang Lei1,
  2. Danmeng Liu1,
  3. Yuan Shen1,
  4. Lili Zhang2,
  5. Shanshan Li1,
  6. Xin Liu1,
  7. Guoshuai Shi1,
  8. Jiamei Li3,
  9. Yaling Zhao1,
  10. Yijun Kang1,
  11. Shaonong Dang1,
  12. Hong Yan4,5,6
  1. 1Department of Epidemiology and Health Statistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China
  2. 2Department of Obstetrics, Shaanxi Provincial People’s Hospital, Xi’an, China
  3. 3Department of Emergency Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
  4. 4Health Science Center, Xi’an Jiaotong University, Xi’an, China
  5. 5Nutrition and Food Safety Engineering Research Center of Shaanxi Province, Xi’an, China
  6. 6Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, China
  1. Correspondence to Shaonong Dang, Department of Epidemiology and Health Statistics School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, China; tjdshn{at} and Hong Yan, Health Science Center, Xi’an Jiaotong University, Xi’an, China; xjtu_yh.paper{at}


To explore the effect of pregnancy-induced hypertension (PIH) on neonatal birth weight and provide the necessary reference value for the maternal and children health service. A cross-sectional study was carried out in Shaanxi Province of China in 2013. And a total of 28 045 singleton live infants and their mothers were recruited using a stratified, multistage, probability-proportional-to-size sampling method. Among the 28 045 women of childbearing age surveyed, multiple linear regression and quantile regression analysis all showed that the birth weight of newborns whose mothers had suffered from PIH during pregnancy was significantly lower than those whose mothers had not suffered from PIH during pregnancy from very low to higher birth weight percentiles (q=0–0.85), an average decrease of 137.45 g (β=−137.45, t=−5.77 and p<0.001). When birth weight was at q=0.90–1.00 percentiles, there was no birth weight difference between two groups. The present cross-sectional study indicated that PIH had an effect of on neonatal birth weight. When pregnant women with PIH are identified then the healthcare professional initiates a closer supervision of their pregnancy in order to ameliorate the status of BP and provide a good intrauterine environment for the fetus. In addition, the gynecologists should admonish the pregnant women that their health is related to the health of their fetus, then gravidas may be more engaged to alert their physician and accept early or preventative interventions. And the healthcare professional should ask and be alert to the issues of hypertension during pregnancy.

  • body weight
  • infant, newborn, diseases
  • pregnancy
  • primary health care

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  • Contributors FL, DL, YS, LZ, SL and GS wrote the original draft. XL, JL, YZ, YK, SD and HY were responsible for the writing, review and editing of the manuscript.

  • Funding The study was sponsored National Natural Science Foundation of China (grant number 81230016), Chinese National Natural Science Foundation for Young Scientists (grant number 81703245), Shaanxi Health and Family Planning Commission (grant number Sxwsjswzfcght2016-013) and Shaanxi natural science basic research (grant number 2014JM2-8153).

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval The survey was approved by the Ethic Review Committee and Academic Committee, Xi’an Jiaotong University College of Medicine, Xi’an, China.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The data collection has been acomplished together by the research team, and the research team has contributed a lot of effort for it. Therefore, this data was kept by the project group, and corresponding authors could been contacted for data information where needed.