Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.
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Funding National Heart, Lung, and Blood Institute (F32HL132471-01; HL090553; HL125335).
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
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