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Overweight and obesity are one of the most relevant health factors; according to the WHO, 39% of people globally are overweight and 13% obese.1 Body weight loss of 3%–5% has been linked to a reduction in risk factors, whereas those with obesity and chronic illness should lose 5%–15% of their body weight to reduce risks.2 Glucose lowering medications, particularly glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RAs), might result in considerable weight loss.3 Semaglutide 2.4 mg (brand name Wegovy) was recently authorized by the Food and Drug Administration for chronic weight management. It is indicated in patients with a body mass index (BMI)≥30 kg/m2, or a BMI≥27 kg/m2 with comorbidities.4
The STEPs studies were the …
Contributors All authors have substantially participated in the preparation and agree to be accountable for all aspects of work related to this Editorial. RV contributed to the conception, literature search, writing, editing, revision, and final approval of the manuscript. RRC contributed to the conception, literature search, writing, editing, revision, and final approval of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.