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We read with great interest the commentary by Lorzadeh and Ghavami1 on our article that reported AMP-activated protein kinase (AMPK)/mechanistic target of rapamycin (mTOR)-independent upregulation of autophagy in the tumor tissue of clear cell renal cell carcinoma (ccRCC) patients.2 We agree with their observation that the somewhat surprising absence of a link between AMPK/mTOR signaling and autophagy induction in ccRCC …
Contributors VT wrote the manuscript; MR, SV, JT, NT, ZS, PN, AV, ZD, UB, and AI provided critical feedback and contributed to the final manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.