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A randomized controlled trial on the effect of dietary guidance on the treatment of Henoch-Schonlein purpura in children
  1. Li Wang1,
  2. Chunyan Yin1,
  3. Meizhen Zhang1,
  4. Hua Mao1,
  5. Huixiang Hao1,
  6. Xiaoting Hu1,
  7. Wanli Xue2
  1. 1 Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, China
  2. 2 Department of Nutrition and Food Safety Research, School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, China
  1. Correspondence to Dr Wanli Xue, Department of Nutrition and Food Safety Research, School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, China; xuewl{at}


The amino acid-based formulae were extensively added to diet of children for the treatment of Henoch-Schonlein purpura (HSP), and the nutrition and growth situation of children were evaluated after giving new dietary intervention. Patients were randomly divided into restricted diet group (n=30) and dietary guidance group (n=30). Besides, 30 cases with bronchiolitis who had normal diet were selected as the control group. The dietary questionnaire was designed to record the types and intakes of various foods taken by children every day, and the intake levels of nutrients were analyzed. Physical examination, biochemical analysis of blood and urine routine were carried out to evaluate the effect of dietary guidance on their growth and development. The results showed that restricted diet group had lower levels of nutrient intake and the actual/recommended percentage. However, overall nutrient intake level of the dietary guidance group was higher, basically equal to the recommended intake level. Besides, the actual intake and actual/recommended percentage of nutrients of dietary guidance group were significantly higher than those of restricted diet group (p<0.05). Dietary guidance can improve nutrients and protein intake of children with HSP, and reduce the relapse of rash and incidence of complications.

  • diet

Data availability statement

Data are available on reasonable request.

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Data availability statement

Data are available on reasonable request.

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  • Contributors LW and WX contributed to the conception and design of the study. All authors participated in the clinical practice, including diagnosis, treatment, consultation and follow-up of patients. CY and MZ contributed to the acquisition of data. HM, HH and XH contributed to the analysis of data. LW wrote the manuscript. CY and WX revised the manuscript. All authors approved the final version of the manuscript.

  • Funding This study was supported by Shaanxi Province social development science and technology project (no. 2016SF-210).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.