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Graft survival effect of HLA-A allele matching parathyroid allotransplantation
  1. Beyza Goncu1,2,
  2. Harika Salepcioglu Kaya3,
  3. Emrah Yucesan4,
  4. Yeliz Emine Ersoy3,2,
  5. Adem Akcakaya3,5
  1. 1 Experimental Research Center, Bezmialem Vakif University, Istanbul, Turkey
  2. 2 Parathyroid Transplantation Laboratory, Bezmialem Vakif University, Istanbul, Turkey
  3. 3 Faculty of Medicine, Department of General Surgery, Bezmialem Vakif University, Istanbul, Turkey
  4. 4 Faculty of Medicine, Department of Medical Biology, Bezmialem Vakif University, Istanbul, Turkey
  5. 5 Organ Transplantation Unit, Bezmialem Vakif University, Istanbul, Turkey
  1. Correspondence to Dr Beyza Goncu, Experimental Research Center, Bezmialem Vakif University, 34093 Istanbul, Turkey; bsgoncu{at}gmail.com

Abstract

Permanent hypoparathyroidism is an endocrine disease that is mostly associated with the disruption of the parathyroid glands during surgery. Allotransplantation is the most promising approach for treatment particularly for its cost-effective and exact curative potential. Herein our aim was to evaluate human leukocyte antigen (HLA)-A allele matching effect on clinical improvement and graft survival after parathyroid transplantation. We performed parathyroid transplantation between ABO/Rh compatible recipient and an unrelated donor who has chronic kidney disease. Preoperative immunological tests include panel reactive antibody, T-flow cytometry crossmatch, B-flow cytometry crossmatch, autoflow cytometry crossmatch, and complement-dependent cytotoxicity crossmatch tests were performed. After histopathological evaluation, half of the resected parathyroid gland cells were isolated and transplanted to the omentum surface by laparoscopy. The transplantation outcome was followed up throughout 382 days. The recipient discharged 2 days after transplantation without any complication. During follow-up, calcium and vitamin D supplementation reduced to a one-third dose; even the intact PTH levels remained low. However, clinical improvement was observed by serum calcium levels. The recipient still continues with low-dose supplementation after 382 days of post-transplantation. Parathyroid cell transplantation to the omental tissue is the most promising option even with only one allele matching for patients with using lifelong high-dose supplementation. Clinical improvements and long-term effect of HLA-A allele matching should be evaluated with more studies and in larger cohorts as well.

  • transplants
  • immunologic tests
  • endocrinology
  • parathyroid hormone

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Footnotes

  • Contributors BG participated in concetp/design, data analysis/interpretation, drafting and critical revision of the article. HSK and EY participated in data interpretation and collection. YEE and AA participated in critical revision and approval of the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Transplantation is carried out with the permission of the Turkish Ministry of Health, National Scientific Board for Transplantation. All of the protocols conformed to the ethical guidelines of the Helsinki Declaration, and written informed consent was obtained from all subjects. Our parathyroid transplantation unit is the first officially permitted center to conduct parathyroid allotransplantation since 2013.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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