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Clinical significance of chitotriosidase in outpatients with advanced heart failure
  1. Sara Cetin Sanlialp1,
  2. Gokay Nar2,
  3. Hande Senol3
  1. 1 The Department of Cardiology, Servergazi State Hospital, Denizli, Turkey
  2. 2 The Department of Cardiology, Pamukkale University Medical Faculty, Denizli, Turkey
  3. 3 The Department of Biostatistics, Pamukkale University Medical Faculty, Denizli, Turkey
  1. Correspondence to Dr Sara Cetin Sanlialp, Cardiology, Servergazi State Hospital, Denizli, Turkey; saracetin{at}


The previous studies have shown that plasma chitotriosidase (CHIT) levels increase in many diseases with inflammation. However, there are no reported studies investigating the relationship between CHIT and chronic heart failure (CHF) which is an inflammatory process. Therefore, we aimed to investigate the role of CHIT in diagnosis and severity of CHF in this study. 36 patients (50% male, mean age 63.17±10.18 years) with left ventricular ejection fraction <40% and 27 controls (44% male, mean age 61.33±8.73 years) were included in this study. Patients with CHF were divided into two groups as ischemic heart failure (IHF) and non-ischemic heart failure (NIHF) according to the underlying etiology. Plasma CHIT and N-terminal pro brain natriuretic peptide (NT-proBNP) levels were measured by ELISA method. Plasma CHIT and NT-proBNP levels were higher in patients with CHF than in controls (CHIT 931.25±461.39 ng/mL, 232.79±61.28 ng/mL, p<0.001; NT-proBNP, 595.31±428.11 pg/mL vs 78.13±30.47 pg/L; p<0.001). Also, the levels of these parameters increased in IHF compared with NIHF (CHIT, 1139.28±495.22 ng/mL, 671.22±237.21 ng/mL, p=0.002; NT-proBNP, 792.87±461.26 pg/mL vs 348.36±202.61 pg/mL, p=0.001) and there was a strong correlation between NT-proBNP and CHIT (r=0.969, p<0.001). According to this study findings, plasma CHIT level increases in CHF and its increased levels are correlated with NT-proBNP which is used diagnosis and prognosis of HF.

  • biomarkers
  • heart failure
  • immunity
  • innate

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  • Contributors SCS, GN and HS contributed towards the writing of this article. SCS contributed towards concept, design, data collection/processing, analysis/interpretation, literature search and writing. GN contributed towards concept, design and data collection/processing. HS contributed towards data analyses/ interpretation.

  • Funding This research was supported by the Scientific Research Projects Coordination Unit of Pamukkale University (Project no.: 2014TPF022)

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by Pamukkale University Medical Faculty Hospital Ethics Review Board in accordance with the Helsinki Declaration (Date: 25.3.2014/5, protocol no.: 60116787-020-20489) and informed consent was obtained from all registered subjects.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information. None.

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