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Association between acute respiratory failure requiring mechanical ventilation and the production of advanced glycation end products
  1. Hawa Edriss1,
  2. Adebayo J Molehin2,3,
  3. Rocio Gavidia2,
  4. Kavitha Selvan4,
  5. Kenneth Nugent2
  1. 1 Pulmonary and Critical Care Medicine, CHI Saint Joseph Hospital, Lexington, Kentucky, United States
  2. 2 Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
  3. 3 Center for Tropical Medicine and Infectious Diseases, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
  4. 4 Department of Medicine, University of Chicago, Chicago, Illinois, USA
  1. Correspondence to Dr Adebayo J Molehin, Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; adebayo.molehin{at}ttuhsc.edu

Abstract

Patients with acute respiratory failure often have hyperglycemia. Elevated glucose levels could cause acute lung injury through the production of advanced glycation end products. We measured glucose, advanced glycation end products, glycated albumin, circulating glycated hemoglobin, and soluble receptor for advanced glycation end product (sRAGE) levels on admission, at 24 hours, and at 72 hours in 40 patients with acute respiratory failure requiring mechanical ventilation. We compared these values with healthy control subjects. The mean age was 63.3±11.2 years. Fifty percent of the patients were women. Thirteen patients (32.5%) died during this hospitalization. The mean maximum glucose level on the day of admission was 215.7±171.1 mg/dL. Compared with control subjects, there was a significant reduction in advanced glycation end product levels (p=0.0001) in the patients at all 3 time points. Circulating glycated hemoglobin levels were significantly higher in patients compared with control subjects. We also observed a moderate increase in glycated albumin levels on admission and at 24 hours when compared with the control samples. Overall sRAGE levels were similar to controls, but patients with dense infiltrates on chest X-ray had increased levels compared with patients who did not have these dense infiltrates on the day of admission. Patients with acute respiratory failure requiring mechanical ventilation have decreased levels of advanced glycation end products and increased levels of circulating glycated hemoglobin. The results from this pilot study suggest that the acute stress associated with respiratory failure might create glycated proteins which could contribute to disease pathogenesis.

  • acute disease
  • hyperglycemia
  • respiration disorders

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Footnotes

  • HE and AJM are joint first authors.

  • HE and AJM contributed equally.

  • Contributors HE and KN designed the study. HE, RG, KS and KN collected patients' consent and processed all biological samples. AJM carried out all experimental assays, data analysis and presentation. AJM and KN drafted the manuscript. HE, RG and KS reviewed the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval This study was approved by the Texas Tech University Health Sciences Center Institutional Review Board in Lubbock, Texas (study number: L 16–1 82). The patient or his/her legally authorized representative gave written and informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information. All data relevant to the study are included in the article or uploaded as supplementary information.

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