Alzheimer’s disease (AD) is a neurodegenerative brain disorder associated with relentlessly progressive cognitive impairment and memory loss. AD pathology proceeds for decades before cognitive deficits become clinically apparent, opening a window for preventative therapy. Imbalance of clearance and buildup of amyloid β and phosphorylated tau proteins in the central nervous system is believed to contribute to AD pathogenesis. However, multiple clinical trials of treatments aimed at averting accumulation of these proteins have yielded little success, and there is still no disease-modifying intervention. Here, we discuss current knowledge of AD pathology and treatment with an emphasis on emerging biomarkers and treatment strategies.
- Alzheimer's disease
- plaque, amyloid
- biomedical research
Statistics from Altmetric.com
Contributors All the authors have read and approved this article. Idea and concept: ABR, BW and MMS. Drafting of the manuscript: ABR, AP, IHG and TW. Critical intellectual contribution, figure drawing and manuscript editing: ADG and JDL.
Funding This work was supported by The Alzheimer's Foundation of America Award (AWD00004772).
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Commissioned; externally peer reviewed.
Data availability statement Brief summary data are preliminary and available upon request.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.