Human adenovirus 36 (Ad-36) causes obesity with increased adiposity, in contrast, Ad-36 infection reduces glucose and lipid metabolism; the results, however, are not consistent. In the current study, the effects of Ad-36 infection on glucose and lipid profile and inflammatory markers in Wistar rats were investigated. Sixty male Wistar rats were randomly divided into infected and control groups. Ad-36 virus suspension was injected in the experimental group rats. Blood samples were collected in the beginning and after 12 weeks in both groups. After 12 weeks, a significant improvement was observed in fasting blood glucose, fasting serum insulin, insulin sensitivity, serum triglycerides and total cholesterol in the infected group compared with the non-infected groups. There were no significant differences in inflammatory biomarkers including tumor necrosis factor-α, interleukin 6 and monocyte chemoattractant protein-1 levels between infected and control groups. This study showed that Ad-36 had favorable effects on glycemic and lipid control in infected rats, but inflammatory biomarker levels were similar for 2 groups. Ad-36 infections could potentially be a new way to develop novel antidiabetic and antihyperlipidemic therapeutic agents.
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Contributors FS, MK and AT designed the research project. FS and AT performed the preparation of cell cultures, viral suspension and injection. FS and MR performed the sampling and data collection. FS, SML and MK analyzed and interpreted the data. FS wrote the draft of the paper. MK, AT and AJM read the final draft and commented on it. All authors read and approved the final manuscript.
Funding This paper is issued from the PhD thesis of FS, which was financially supported by grant (NRC 9204) from Vice-Chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval The ethical committee of experimental animal care at Ahvaz Jundishapur University of Medical Sciences (NRC 9204) approved the study. The study was performed in accordance with the National Research Council (US) Committee for Guide for the Care and Use of Laboratory Animals, 8th Edition.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available upon reasonable request. Data are available by emailing MK (email@example.com) and FS (firstname.lastname@example.org).