Article Text

Download PDFPDF
Bedside clinical assessment predicts recurrence after hospitalization due to viral lower respiratory tract infection in young children
  1. Maria Arroyo1,
  2. Kyle P Salka1,
  3. Geovanny F Perez2,
  4. Carlos E Rodriguez-Martinez3,4,
  5. Jose A Castro-Rodriguez5,
  6. Gustavo Nino6
  1. 1 Pediatric Pulmonary and Sleep Medicine, Childrens National Medical Center, Washington, DC, USA
  2. 2 Department of Pulmonary, Children's National Health System, Washington, DC, USA
  3. 3 Universidad Nacional de Colombia, Bogota, Colombia
  4. 4 Universidad El Bosque Facultad de Medicina, Bogota, Colombia
  5. 5 Division of Pediatrics, Pontificia Universidad Catolica de Chile, Santiago, Chile
  6. 6 Childrens National Medical Center, Washington, DC, USA
  1. Correspondence to Dr Maria Arroyo, Pediatric Pulmonary and Sleep Medicine, Childrens National Medical Center, Washington, DC 20010, USA; marroyo{at}


Infants requiring hospitalization due to a viral lower respiratory tract infection (LRTI) have a high risk of developing recurrent respiratory illnesses in early life and asthma beyond childhood. Notably, all validated clinical scales for viral LRTI have focused on predicting acute severity instead of recurrence. We present a novel clinical approach combining individual risk factors with bedside clinical parameters to predict recurrence after viral LRTI hospitalization in young children. A retrospective longitudinal cohort of young children (≤3 years) designed to define clinical predictive factors of recurrent respiratory illnesses within 12 months after hospitalization due to PCR-confirmed viral LRTI. Data collection was through electronic medical record. We included 138 children hospitalized with viral LRTI. Using automatic stepwise logistic model selection, we found that the strongest predictors of recurrence in infants hospitalized for the first time were severe prematurity (≤32 weeks’ gestational age, OR=5.19; 95% CI 1.76 to 15.32; p=0.002) and a clinical score that weighted hypoxemia, subcostal retractions and wheezing (OR=3.33; 95% CI 1.59 to 6.98; p<0.001). After the first hospitalization, the strongest predictors of subsequent episodes were wheezing (OR=5.62; 95% CI 1.03 to 30.62; p=0.04) and family history of asthma (OR=5.39; 95% CI 1.04 to 27.96; p=0.04). We found that integrating individual risk factors (eg, prematurity or family history of asthma) with bedside clinical assessment (eg, wheezing, subcostal retractions or hypoxemia) can predict the risk of recurrence after viral LRTI hospitalization in infants. This strategy may enable clinically oriented subsetting of infants with viral LRTI based on individual predictors for recurrent respiratory illnesses during early life.

  • infant, newborn, diseases
  • respiratory tract diseases
  • asthma
  • clinical research

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors All authors are responsible for the reported research and have participated in the concept and design; analysis and interpretation of data; and drafting or revising of the manuscript, and they have approved the manuscript as submitted.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.