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Lymphoma classification: morphology to molecular
  1. Robert T Means Jr1,2,3
  1. 1 Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
  2. 2 Department of Medical Education, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
  3. 3 Department of Pathology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
  1. Correspondence to Dr Robert T Means, Jr, Department of Internal Medicine, Building 2/Room 109, P.O. Box 70622, East Tennessee State University, Johnson City, TN 37614, USA; meansr{at}etsu.edu

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An underlying theme in the history of medicine is progressive refinement in the understanding of disease and approaches to therapy guided by the evolution of technology applied to diagnosis. In hematology, with its origins in the application of microscopy to clinical diagnosis in the 19th century, this theme may be more readily visible than in other subspecialties.1 A characteristic example is chronic myelogenous leukemia (CML), initially diagnosed on the basis of a characteristic blood count and myeloproliferative clinical picture and managed with therapy aimed at white blood count reduction. As the use of cytogenetics testing became more common, the diagnosis of CML became dependent on demonstration of a characteristic translocation (t(9;22)(q34;q11); the ‘Philadelphia chromosome’).2 As molecular genetics progressed, this was …

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Footnotes

  • Contributors RTM is the sole author of this submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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