Preptin is a peptide synthesized and secreted accompanied with insulin from pancreatic β cells. Here, we tested the hypothesis that serum preptin concentrations are correlated with diabetic nephropathy (DN). Our study was performed in a population of 234 patients with type 2 diabetes mellitus (T2DM) and 78 healthy subjects. Patients with T2DM were divided into three groups: normoalbuminuria group (DN0, n=106), microalbuminuria group (DN1, n=90), and macroalbuminuria group (DN2, n=38) according to urine albumin to creatinine ratio (ACR). Serum preptin concentrations were significantly increased in the three T2DM subgroups than those in the controls. DN2 group showed significantly higher serum preptin concentrations compared with DN0 and DN1 groups. Moreover, DN1 group had higher serum preptin concentrations than DN0 group. Serum preptin was correlated with a higher risk of T2DM and DN after logistic regression analysis. Simply linear regression analysis demonstrated a positive correlation between serum preptin and gender, body mass index (BMI), blood urea nitrogen, creatinine, ACR, and a negative correlation between serum preptin and glomerular filtration rate, metformin, acarbose treatment. Gender, BMI, and ACR were still positively correlated with serum preptin after multiple linear regression analysis. Our findings indicate that serum preptin concentrations are associated with renal function and DN.
- diabetic nephropathies
- diabetes mellitus
- diabetes complications
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Contributors JL and LH researched literature and conceived the study. RW, WZ, and WH were involved in protocol development, gaining ethical approval, patient recruitment, and data analysis. FY collected and analyzed the data of the oral antidiabetes drug, and helped to answer the reviewer’s question. RW wrote the first draft of the manuscript and LW revised the grammar of this manuscript. All authors reviewed and edited the manuscript and approved the final version of the manuscript.
Funding Funded by The Doctoral Program of Natural Science Foundation of Shandong Province (ZR2016HB35) and The Youth Funding of Qilu Hospital of Shandong University (Qingdao) (QDKY2018LH01).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Patient consent for publication Not required.