Population-based cohort study investigating the risk of depression and other psychiatric disorders for patients with overactive bladder (OAB) syndrome is unavailable. This study investigated the subsequent risk of psychiatric disorders among patients with OAB in an Asian population. Using data from the National Health Insurance Research Database of Taiwan, we established a cohort with 811 patients in an exposed group with OAB between January 1, 2000 and December 31, 2000, and a non-exposed group, without OAB, of 2433 patients without OAB matched by age and year of diagnosis. The occurrence of psychiatric disorders and Cox regression model measured adjusted HRs (aHR) were monitored until the end of 2013. The overall incidence of psychiatric disorders was 41.7% higher in the exposed group with OAB than in the non-exposed group without OAB (14.2% vs 10.1%, p<0.001), with an aHR of 1.34 (95% CI 1.12 to 1.80, p<0.001) for the OAB cohort. OAB was associated with the increased risk of dementia, anxiety, depressive, sleep, and psychotic disorders, with aHRs as 1.53 (p=0.040), 1.61 (p<0.001), 2.10 (p<0.001), 1.43 (p<0.001), and 2.49 (p=0.002), respectively. The risk of psychiatric disorders, including depression and anxiety, is significantly higher in patients with OAB than in those without OAB. Evaluation of psychiatric status in patients with OAB is strongly recommended.
- overactive bladder syndrome
- psychiatric disorders
- National Health Insurance Research Database
- cohort study
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Contributors NST and WCC conceived the study, participated in its design and coordination, data interpretation, performed the statistical analysis and drafted the manuscript. WCC, CHC, HWY, HAC, RBL and YCK participated in the design of the study and data interpretation. CBY, SYH and WSC participated in the statistical analysis and data interpretation. NST wrote the paper. All authors have read and approved the final manuscript as submitted.
Funding This work was supported by Tri-Service General Hospital Research Foundation (grant numbers TSGH-C105-130, TSGH-C106-106, TSGH-C107-106, TSGH-C107-004).
Competing interests None declared.
Patient consent Not required.
Ethics approval This study was conducted in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki). The Institutional Review Board of the Tri-Service General Hospital approved this study and waived the need of individual consents since all the identification data were encrypted in the NHIRD (IRB number 1-104-05-145 and 1-106-05-055).
Provenance and peer review Not commissioned; externally peer reviewed.
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