Article Text

Prevalence and risk factors of acquired long QT syndrome in hospitalized patients with chronic kidney disease
  1. Peng Liu,
  2. Dan Han,
  3. Xuanzi Sun,
  4. Hui Tan,
  5. Zhigang Wang,
  6. Chao Liu,
  7. Yali Zhang,
  8. Bailin Li,
  9. Chaofeng Sun,
  10. Rui Shi,
  11. Guoliang Li
  1. First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
  1. Correspondence to Dr Guoliang Li, Arrhythmia Unit, Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China; liguoliang_med{at}


Patients with chronic kidney disease (CKD) have a high risk of fatal arrhythmias. The extended severe corrected QT (QTc) interval is a hallmark of ventricular arrhythmias and sudden cardiac death. The objective of this study was to evaluate the prevalence of acquired long QT syndrome (aLQTS) in hospitalized patients with CKD and search for potential risk factors to improve clinical risk stratification in patients with CKD. Information about patients with CKD was retrospectively collected in our hospital between January 2013 and June 2017. The prevalence of aLQTS in different stages of CKD was evaluated. The common risk factors for QTc prolongation in patients with CKD were compiled, and multivariable logistic regression analysis was used to evaluate how each factor was related to aLQTS in CKD. A total of 804 patients with CKD (299 females, 37.2%) participated in our study. The prevalence of aLQTS among all 804 patients was 56.97%, and the prevalence of QTc prolongation (>500 ms) was 10.07%. Among the elderly, impaired kidney function, hemodialysis, low serum potassium and low left ventricular ejection fraction (LVEF) were associated with QTc prolongation in patients with CKD. The prevalence of aLQTS is much higher and increases with the decline of kidney function in hospitalized patients with CKD, which is related to older age, impaired kidney function, hemodialysis, serum potassium and low LVEF.

  • cardiovascular diseases
  • renal insufficiency, chronic
  • electrocardiography

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  • Contributors PL and GL developed the idea for the study. They participated in its design, coordination and data interpretation. They performed the statistical analysis and drafted the manuscript. DH and XS participated in the design of the study and data interpretation. HT, ZW and CL participated in the design of the study and data interpretation. YZ, BL and CS participated in the statistical analysis and data interpretation. PL wrote the paper. All authors have read and approved the final manuscript as submitted.

  • Funding This study was supported by funding from the international science and technology cooperation projects in Shaanxi Province (2016KW-025) and the fundamental research funds for the central universities (1191320098).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This study was approved by the ethics committee of the First Affiliated Hospital of Xi’an Jiao Tong University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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