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Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation
  1. Noussa Ragab El Basha1,
  2. Hanan Mohsen Osman1,
  3. Amaal Abdo Abdelaal2,
  4. Salma Mohamed Saed2,
  5. Hala Hamdy Shaaban1
  1. 1 Pediatric Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Egypt
  2. 2 Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
  1. Correspondence to Dr Noussa Ragab El Basha, Pediatric Department, Cairo University Kasr Alainy Faculty of Medicine, Cairo 12613, Egypt; noussaelbasha3{at}


Children with severe asthma or acute asthma exacerbation may encounter difficulties in performing pulmonary function tests. In this situation, serum biomarkers can play a great role in evaluation of such patients. The aim of this study was to estimate the serum levels of human chitinase-3-like protein 1 (YKL40) and periostin in a group of Egyptian children with asthma during acute asthma exacerbation and in stable asthmatics compared with healthy control, and to correlate these findings with the severity of asthma. This cross-sectional study enrolled 120 childrenwith asthma with different degrees of asthma severity, according to the Global Initiative for Asthma guidelines, along with 60 age-matched and sex-matched healthy control. A complete blood count and an estimation of serum periostin and YKL40 levels were performed for all cases and control. Individual and mean values of periostin and YKL40 were significantly higher during acute asthma exacerbations, p<0.001. A highly significant relation between serum levels of periostin and YKL40 and asthma severity, p value for each was <0.001. Absolute eosinophil count was significantly correlated with the serum periostin levels in stable asthmatic group (p=0.01) only. There was significantly positive correlation (P<0.001) between both markers in stable asthmatic group. Spearman’s correlation coefficient shows a statistically significant positive correlation between both markers and patient’s age and duration of asthma, p value for each was 0.001. These findings highlight the importance of periostin and YKL40 as serum biomarkers for assessment of asthma severity and acute asthma exacerbations in children with asthma.

  • asthma
  • biological markers
  • eosinophils
  • phenotype

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  • Contributors NREB, HMO, HHS conceived and designed the study. AAA, SMS performed the laboratory work. NREB, HMO and HHS analysed the data and wrote the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval This study was approved by the Scientific Ethics Committee of the Faculty of Medicine of Cairo University, Egypt.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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