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A 8-year population-based cohort study of irritable bowel syndrome in childhood with history of atopic dermatitis
  1. Jeng-Dau Tsai1,2,
  2. I-Chung Wang3,
  3. Te-Chun Shen4,5,
  4. Cheng-Li Lin6,7,
  5. Chang-Ching Wei3,5
  1. 1 Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
  2. 2 Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  3. 3 Children’s Hospital, China Medical University Hospital, Taichung, Taiwan
  4. 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
  5. 5 College of Medicine, China Medical University, Taichung, Taiwan
  6. 6 Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  7. 7 Institute of Biostatistics, China Medical University, Taichung, Taiwan
  1. Correspondence to Dr Chang-Ching Wei, Children’s Hospital, China Medical University Hospital, Taichung 402, Taiwan; weilonger{at}gmail.com

Abstract

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder affecting a large number of people worldwide. Based on the concept of central sensitization, we conducted a population-based cohort analysis to investigate the risk of IBS in children with atopic dermatitis (AD) as one of the first steps in the atopic march. From 2000 to 2007, 1 20 014 children with newly diagnosed AD and 1 20 014 randomly selected non-AD controls were included in the study. By the end of 2008, incidences of IBS in both cohorts and the AD cohort to non-AD cohort hazard ratios (HRs) and CIs were measured. The incidence of IBS during the study period was 1.45-fold greater (95% CI: 1.32 to 1.59) in the AD cohort than in the non-AD cohort (18.8 vs 12.9 per 10 000 person-years). The AD to non-AD HR of IBS was greater for girls (1.60, 95% CI: 1.39 to 1.85) and children≥12 years (1.59, 95% CI: 1.23 to 2.05). The HR of IBS in AD children increased from 0.84 (95% CI: 0.75 to 0.94) for those with ≤3 AD related visits to 16.7 (95% CI: 14.7 to 18.9) for those with >5 visits (P<0.0001, by the trend test). AD children had a greater risk of developing IBS. Further research is needed to clarify the role of allergy in the pathogenesis of IBS.

  • inflammation
  • dermatitis, atopic

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Footnotes

  • Contributors I-CW and J-DT made equal contribution to this study. C-CW, J-DT, and T-CS conceptualized and designed the study, drafted the manuscript, and approved the final manuscript as submitted. C-LL conducted the initial analyses, reviewed and revised the manuscript, and approved the final manuscript as submitted. C-CW and J-DT coordinated and supervised the data collection, critically reviewed the manuscript and approved the final manuscript as submitted.

  • Funding The study was supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004), China Medical University Hospital (DMR-106-053), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo AoshimaMemorial Funds, Japan.

  • Competing interests None declared.

  • Patient consent Guardian consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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