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In the communication by Feng et al titled ‘Anti-inflammatory effects of simvastatin during the resolution phase of experimentally formed venous thrombi’, the authors demonstrated that simvastatin targets inflammatory pathways in venous thrombosis.1 Using a rabbit model of thrombus induced in the inferior vena cava, they found that simvastatin alone and in conjunction with heparin reduced plasma level and local expression of P-selectin, interleukin (IL)-6 and monocyte chemoattractant protein-1 (MCP-1). Animals …
Competing interests Jose Antonio Diaz, MD is on the Board of Directors of the American Venous Forum, as a Research Council Chair.
Provenance and peer review Not commissioned; externally peer reviewed.
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