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Letter to the Editor
Statins in venous thrombosis: more evidence, more basic science findings
  1. Olivia R Palmer1,
  2. Maxim E Shaydakov2,
  3. Joshua Rainey2,
  4. Melanie L Flaherty2,
  5. Jose Antonio Diaz2
  1. 1 Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
  2. 2 Department of Surgery and Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Jose Antonio Diaz, Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA; josediaz{at}

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In the communication by Feng et al titled ‘Anti-inflammatory effects of simvastatin during the resolution phase of experimentally formed venous thrombi’, the authors demonstrated that simvastatin targets inflammatory pathways in venous thrombosis.1 Using a rabbit model of thrombus induced in the inferior vena cava, they found that simvastatin alone and in conjunction with heparin reduced plasma level and local expression of P-selectin, interleukin (IL)-6 and monocyte chemoattractant protein-1 (MCP-1). Animals …

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  • Competing interests Jose Antonio Diaz, MD is on the Board of Directors of the American Venous Forum, as a Research Council Chair.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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