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Association of chronic obstructive pulmonary disease and postresection lung cancer survival: a systematic review and meta-analysis
  1. Lan-Eng Tan,
  2. Razak A M,
  3. Chor-Shen Lim
  1. Institute of Respiratory Medicine, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia
  1. Correspondence to Dr Chor-Shen Lim, Institute of Respiratory Medicine, Kuala Lumpur General Hospital, Jalan Pahang, Kuala Lumpur 50590, Malaysia; chorshen{at}


Patients with lung cancer often have chronic obstructive pulmonary disease (COPD), but the impact of COPD on postresection survival of patients with lung cancer is unclear. This study evaluated the impact of COPD on survival of patients with lung cancer following pulmonary resection. Databases searched included PubMed, Cochrane, and Embase until March 2016. Study outcomes were overall survival and pulmonary complication rate (pneumonia, bronchial fistula, and prolonged mechanical ventilation). 6 studies with a total of 3761 patients were included. The presence of COPD was associated with lower overall survival, increased frequency of pneumonia, and prolonged mechanical ventilation (p values ≤0.001). COPD had no influence on bronchial fistula development (p=0.098). In summary, COPD was associated with poorer survival and an increased frequency of certain adverse events in patients with lung cancer following resection.

  • Carcinoma
  • Chronic Disease
  • Lung Diseases

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  • Contributors L-ET contributed to the analysis and interpretation of data, drafting of the manuscript, statistical analysis, definition of intellectual content and literature research. RAM contributed to the study supervision and provided administrative, technical or material support. C-SL contributed to the conception and design of the study, acquisition of data, critical revision of the manuscript, and is the guarantor of integrity of the entire study, statistical analysis, and definition of intellectual content. All the authors gave their final approval of the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.