Objectives Patient medication compliance can be seriously affected by a bitter taste. There are various taste-masking agents, but they urgently need to be improved. Mesoporous molecular sieves are a type of 3-dimensional nanostructure that has a regular pore diameter (2–50 nm), has a large surface area, and is non-toxic. These structures are widely used in biomedicine but their application in the drug taste-masking field has not previously been reported. The objective of this investigation was to prepare three different mesoporous molecular sieves (MCM-41, MCM-48 and HMSS) and to determine their masking properties through volunteer tasting.
Methods MCM-41, MCM-48 and HMSS were synthesized using a hydrothermal method. The bitter-tasting drug cetirizine (CTH) was used as the model drug. CTH-sieve composites were prepared using the impregnation method and the composites were characterized by means of XRD, FTIR, nitrogen physical adsorption and TGA. Three commonly used taste-masking agents were used as contrast to mask the bitter flavor of CTH.
Results MCM-41, MCM48 and HMSS showed a large CTH loading capacity of 25.12%, 32.91% and 50.00%, respectively, and effectively reduced the bitter taste of CTH by covering the oral mucous membrane thus reducing irritation.
Conclusions The pore structure and large surface area of the sieves improved taste-masking efficiency compared with common taste-masking agents. Mesoporous molecular sieves have the potential to increase the efficacy of taste-masking agents.
Acknowledgments This research was financially supported by Jilin Provincial Development and Reform Commission Industrial Technology Research and Development Funds (Grant No. 2014Y091).
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.