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Characterization of immune cell phenotypes in adults with autism spectrum disorders
  1. José Manuel López-Cacho1,
  2. Soledad Gallardo1,
  3. Manuel Posada2,
  4. Miriam Aguerri1,
  5. David Calzada1,
  6. Teodoro Mayayo3,
  7. Carlos Lahoz1,4,
  8. Blanca Cárdaba1,4
  1. 1Department of Immunology, IIS-Fundación Jiménez Díaz-UAM, Madrid, Spain
  2. 2Institute for Rare Disease Research, Instituto de Salud Carlos III, Biomedical Research Network on Rare Diseases (CIBERER), Madrid, Spain
  3. 3Department of Sani-Red SL, Parque Científico de Barcelona, Barcelona, Spain
  4. 4Biomedical Research Network on Respiratory Diseases, (CIBERES), Madrid, Spain
  1. Correspondence to Dr B Cárdaba, Department of Immunology, IIS-Fundación Jiménez Díaz, Avda Reyes Católicos N° 2, Madrid 28040, Spain; bcardaba{at}fjd.es

Abstract

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impairments in verbal and non-verbal communication, impaired social interactions and repetitive behaviors. There is evidence of a link between ASD symptoms and immune dysfunction, but few studies have been performed in adult patients to confirm this. In this work, we used flow cytometry to study immunological differences in peripheral blood mononuclear cells from 59 adult patients and 26 healthy control subjects to identify possible immune cell profiles related with this group of disorders. We analyzed six immune cell subpopulations (ie, B-cells, CD4+ and CD8+ T-cells, NK, NKT cells, and monocytes) and their corresponding stages of apoptosis and activation. The most noteworthy results showed that, compared to healthy controls, patients had increased percentages of CD8+ T-cells and B-cells, and a decrease in the percentage of NKT cells. Regarding CD25 expression, we found overall CD25+ overexpression, primarily in NK and NKT cells. Apoptosis percentage showed an increasing trend only in monocytes of patients. These data support a link between ASD and immune dysfunction, suggesting that specific cellular phenotypes and/or activation status of immune cells may be relevant in adult ASD.

  • Biological Markers
  • Biomedical Research
  • Lymphocytes
  • Phenotype

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