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Endothelin-1 concentrations are correlated with the severity of knee osteoarthritis
  1. Zhe Zhao1,
  2. Enqi Li2,
  3. Qing Cao2,
  4. Jie Sun2,
  5. Baotong Ma2
  1. 1Department of Surgery of Traditional Chinese Medicine, Tianjin Hospital, Tianjin, People's Republic of China
  2. 2Department of Orthopaedic Trauma, Tianjin Hospital, Tianjin, People's Republic of China
  1. Correspondence to Dr Baotong Ma, Department of Orthopaedic Trauma, Tianjin Hospital, 406 South Jiefang Road, Tianjin 300211, People's Republic of China; mabtong{at}


Endothelin-1, a potent vasoconstrictor regulator, contributes to articular cartilage destruction. Therefore, we aim to assess the correlation of endothelin-1 concentrations with the development and severity of knee osteoarthritis (OA). This study included a population of 209 patients with knee OA. Kellgren-Lawrence (KL) grading was utilized to score the severity of OA. The case group had higher serum endothelin-1 concentrations than controls. Patients with knee OA with a relatively higher grade showed significantly elevated serum and synovial fluid (SF) endothelin-1 concentrations compared with those with lower KL grades. A significant correlation was found between serum and SF endothelin-1 concentrations and KL grades. Serum and SF endothelin-1 concentrations are correlated with the development and progression of knee OA.

  • Osteoarthritis
  • Inflammation

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